7. Nina Dobrev and Ian Somerhalder
Maybe this one is a bit of a stretch, but once Nina Dobrev and Ian Somerhalder broke up in real life, The Vampire Diaries went into a creative tailspin that saw their characters spending less and less time together until Dobrev ultimately left the show. Meanwhile, Ian engaged in a very public, whirlwind courtship and marriage with their former mutual friend Nikki Reed. Possibly all a coincidence, but we doubt it.