3. Zofran – Anit-Nausea and Vomiting Drug
Administered to combat chemotherapy-induced nausea and vomiting, Zofran has also found off-label use in situations where nausea and vomiting occur. While it may seem like a God-send for pregnant women, they are strongly advised not to use this drug.
Studies have linked Zofran usage to an increased risk of developing birth defects. The incidence of cleft palates, club feet, and craniosynostosis are all higher in mothers who take Zofran. The main component, Ondansetron, works by affecting serotonin levels in the brain. In pregnant women, it can cross the placenta and affect the still-developing brain of a fetus.
Despite this, the manufacturer, GSK, still marketed the drug to pregnant women, even though it wasn’t approved by the FDA to do so. The lawsuits filed also accuse GSK of paying doctors to prescribe the drug.
With over a million women taking the drug every year, GSK earned millions in revenue. In 2012, the company settled the largest health care fraud settlement in U.S. history after the company agreed to a $3 billion payment.
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