9. Katherine Heigl
After her breakthrough as Dr. Izzie Stevens on the smash hit TV show Grey’s Anatomy, Katherine Heigl took over the rom-com genre in the late-2000s. SEE ALSO: Top 10 highest paid actresses in the world – See how much they earn annually 9+Photos)
Between 2007 and 2010, she starred in Knocked Up, 27 Dresses, The Ugly Truth, Killers, and Life As We Know It, all as the female lead. Somewhere along the line, the anti-Heigl backlash began, drawing attention to her diva rep on the set of Grey’s and her icy relationship with male comedy icons Judd Apatow and Seth Rogen. It also became difficult to separate the actress from the uptight character she always seemed to play.
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